JSSS Journal of Sensors and Sensor Systems JSSS J. Sens. Sens. Syst. 2194-878X Copernicus Publications Göttingen, Germany 10.5194/jsss-2-165-2013 Characterization and simulation of peristaltic micropumps Busek M. 1 Nötzel M. 1 Polk C. 1 Sonntag F. 1 Fraunhofer IWS Dresden, Dresden, Germany 18 10 2013 2 2 165 169 Copyright: © 2013 M. Busek et al. 2013 This work is licensed under the Creative Commons Attribution 3.0 Unported License. To view a copy of this licence, visit https://creativecommons.org/licenses/by/3.0/ This article is available from https://jsss.copernicus.org/articles/2/165/2013/jsss-2-165-2013.html The full text article is available as a PDF file from https://jsss.copernicus.org/articles/2/165/2013/jsss-2-165-2013.pdf

The aim of the work is to find an analytical model of a pneumatic micropump which was integrated into a cell-culture system. This allows the estimation of peak velocities and wall-shear stress influencing the cultured cells in our multi-organ-chip (MOC) with respect to the applied pressure and the geometric properties of the pump. By adjusting those parameters, one can imitate physiological or pathological heart activity. The calculated flow within the MOC was compared to experimental results obtained via the non-invasive micro-PIV method.

 References Baker, M.: A living system on a chip, Nature, 471, 661–665, 2011. Bourouina, T. and Grandchamp, J.-P.: Modeling micropumps with electrical equivalent networks, J. Micromech. Microeng., 6, 398–404, 1996. Huang, C.-W., Huang, S.-W., and Lee, G.-B.: Pneumatic micropumps with serially connected actuation chambers, J. Micromech. Microeng., 16, 2265–2272, 2006. Huang, S.-B., Wu, M.-H., Cui, Z., Cui, Z., and Lee, G.-B.: A membrane-based serpentine-shape pneumatic micropump with pumping performance modulated by fluidic resistance, J. Micromech. Microeng., 18, 045008, <a href="http://dx.doi.org/10.1088/0960-1317/18/4/045008">https://doi.org/10.1088/0960-1317/18/4/045008</a>, 2008. Lindken, R.: Micro-particle image velocimetry (μPIV): Recent developments, applications, and guidelines, Lab Chip, 9, 2551–2567, 2009. Marx, U., Walles, H., Hoffmann, S., Lindner, G., Horland, R., Sonntag, F., Klotzbach, U., Sakharov, D., Tonevitsky, A., and Lauster, R.: "Human-on-a-chip" Developments: A Translational Cutting-edge Alternative to Systemic Safety Assessment and Efficiency Evaluation of Substances in Laboratory Animals and Man?, ATLA, 40, 235–257, 2012. Nedelcu, O. T., Morelle, J.-L., Tibeica, C., Voccia, S., Codreanu, I., and Dahms, S.: Modelling and simulation of a pneumatically actuated micropump, Semiconductor Conference, 2007. Schimek, K., Busek, M., Brincker, S., Groth, B., Hoffmann, S., Lauster, R., Lindner, G., Lorenz, A., Menzel, U., Sonntag, F., Walles, H., Marx, U., and Horland, R.: Integrating biological vasculature into a multi-organ-chip microsystem, Lab Chip, 13, 3588–3598, 2013. Sonntag, F., Schilling, N., Mader, K., Gruchow, M., Klotzbach, U., Lindner, G., Horland, R., Wagner, I., Lauster, R., Howitz, S., Hoffmann, S., and Marx, U.: Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure, J. Biotechnol., 148, 70–75, 2010. Thangawng, A. L., Ruoff, R. S., Swartz, M. A., and Glucksberg, M. R.: An ultra-thin PDMS membrane as a bio/micro–nano interface: fabrication and characterization, Bomed. M., 9, 587–595, 2007. Timoshenko, S. and Woinowsky-Krieger, S.: Theory of plates and shells, 2nd Edn., McGraw-Hill Book Company, 1959. Wagner, I., Materne, E.-M., Brincker, S., Süßbier, U., Frädrich, C., Busek, M., Sonntag, F., Sakharov, D., Trushkin, E., Tonevitsky, A., Lauster, R., and Marx, U.: A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture, Lab Chip, 13, 3538–3547, 2013. Winkelmann, C., Luo, Y., Lode, A., Gelinsky, M., Marx, U., Busek, M., Schmieder, F., and Sonntag, F.: Charakterisierung von in Lab-on-a-Chip Systemen eingebetteten Hohlfasern, Tech. Mess., 80, 147–154, 2013. Wu, M.-H., Huang, S.-B., Cui, Z., Cui, Z., and Lee, G.-B.: A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture, Biomed. M., 10, 309–319, 2008.