While electronic noses are designed to detect volatile organic compounds (VOCs) in complex odors, materials within sampling chambers and lines can emit their own gases, altering sensor responses. Our study confirmed that silicone and 3D-printed resin release compounds that poison sensors and reduce life span. In contrast, polyetheretherketone (PEEK) is a stable material that does not cause poisoning. Understanding these effects is crucial for designing reliable gas sensing platforms, ensuring accurate gas detection in different applications.