Articles | Volume 5, issue 1
https://doi.org/10.5194/jsss-5-221-2016
https://doi.org/10.5194/jsss-5-221-2016
Regular research article
 | 
24 Jun 2016
Regular research article |  | 24 Jun 2016

Design, characterization, and modeling of microcirculation systems with integrated oxygenators

Mathias Busek, Stefan Gruenzner, Tobias Steege, Florian Schmieder, Udo Klotzbach, and Frank Sonntag

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Short summary
A novel cell-cultivation platform with small circulating volume and included oxygen controlling system is presented. This system may be used to investigate the influence of oxygen restriction, called hypoxia, to cultivated human cells and therefore helps to reduce animal testing in this field of research. Furthermore, a mathematic model of the oxygen transport is presented which may be utilized to produce well-defined oxygen microenvironments.