Articles | Volume 5, issue 1
https://doi.org/10.5194/jsss-5-221-2016
https://doi.org/10.5194/jsss-5-221-2016
Regular research article
 | 
24 Jun 2016
Regular research article |  | 24 Jun 2016

Design, characterization, and modeling of microcirculation systems with integrated oxygenators

Mathias Busek, Stefan Gruenzner, Tobias Steege, Florian Schmieder, Udo Klotzbach, and Frank Sonntag

Related authors

Characterization and simulation of peristaltic micropumps
M. Busek, M. Nötzel, C. Polk, and F. Sonntag
J. Sens. Sens. Syst., 2, 165–169, https://doi.org/10.5194/jsss-2-165-2013,https://doi.org/10.5194/jsss-2-165-2013, 2013

Related subject area

Applications: Biotechnology
Development and characterisation of a new fluorescence sensor for online monitoring of bioprocesses
Jan C. König, Tobias Steinwedel, Dörte Solle, Patrick Lindner, Ingo de Vries, Thorleif Hentrop, Michael Findeis, Gernot T. John, Thomas Scheper, and Sascha Beutel
J. Sens. Sens. Syst., 7, 461–467, https://doi.org/10.5194/jsss-7-461-2018,https://doi.org/10.5194/jsss-7-461-2018, 2018
Short summary
Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform
Stefan Beißner, Jan-Wilhelm Thies, Christopher Bechthold, Philipp Kuhn, Bettina Thürmann, Stefan Dübel, and Andreas Dietzel
J. Sens. Sens. Syst., 6, 341–350, https://doi.org/10.5194/jsss-6-341-2017,https://doi.org/10.5194/jsss-6-341-2017, 2017
Microfluidic measurement of cell motility in response to applied non-homogeneous DC electric fields
Marisa Rio, Sharanya Bola, Richard H. W. Funk, and Gerald Gerlach
J. Sens. Sens. Syst., 5, 237–243, https://doi.org/10.5194/jsss-5-237-2016,https://doi.org/10.5194/jsss-5-237-2016, 2016
Short summary

Cited articles

Abid, H. J., Chen, J., and Nassar, A. A.: Equivalent Air Spring Suspension Model for Quarter-Passive Model of Passenger Vehicles, International Scholarly Research Notices, 2015, 1–6, https://doi.org/10.1155/2015/974020, 2015.
Abramowitz, M. and Stegun, I. A.: Handbook of mathematical functions: With formulas, graphs, and mathematical tables, Dover books on mathematics, Dover Publications, New York, USA, XIV, 1046, 1970.
Ataç, B., Wagner, I., Horland, R., Lauster, R., Marx, U., Tonevitsky, A. G., Azar, R. P., and Lindner, G.: Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion, Lab Chip, 13, 3555–3561, https://doi.org/10.1039/c3lc50227a, 2013.
Baker, M.: Tissue models: a living system on a chip, Nature, 471, 661–665, https://doi.org/10.1038/471661a, 2011.
Bhatia, S. N. and Ingber, D. E.: Microfluidic organs-on-chips, Nature biotechnology, 32, 760–772, https://doi.org/10.1038/nbt.2989, 2014.
Download
Short summary
A novel cell-cultivation platform with small circulating volume and included oxygen controlling system is presented. This system may be used to investigate the influence of oxygen restriction, called hypoxia, to cultivated human cells and therefore helps to reduce animal testing in this field of research. Furthermore, a mathematic model of the oxygen transport is presented which may be utilized to produce well-defined oxygen microenvironments.