Articles | Volume 9, issue 2
https://doi.org/10.5194/jsss-9-251-2020
https://doi.org/10.5194/jsss-9-251-2020
Regular research article
 | 
19 Aug 2020
Regular research article |  | 19 Aug 2020

In-line monitoring of electrolytes and urea during continuous renal replacement therapy

Marc Berger, Merle Sehlmeyer, Flora Sellering, Hannes Röhrich, Thorsten Perl, Hussam Mansour, Daniel Baasner, and Stefan Zimmermann

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Cited articles

Bagshaw, S. M., George, C., and Bellomo, R.: Early acute kidney injury and sepsis: A multicentre evaluation, Critical care (London, England), 12, R47, https://doi.org/10.1186/cc6863, 2008. 
Baue, A. E., Faist, E., and Fry, D. E.: Multiple Organ Failure: Pathophysiology, Prevention, and Therapy, N, Springer New York, New York, 1, 2000. 
Bellomo, R., Kellum, J. A., and Ronco, C.: Acute kidney injury, The Lancet, 380, 756–766, https://doi.org/10.1016/S0140-6736(11)61454-2, 2012. 
Bénéteau-Burnat, B., Pernet, P., Pilon, A., Latour, D., Goujon, S., Feuillu, A., and Vaubourdolle, M.: Evaluation of the GEM Premier 4000: a compact blood gas CO-Oximeter and electrolyte analyzer for point-of-care and laboratory testing, Clin. Chem. Lab. Med., 46, 271–279, https://doi.org/10.1515/CCLM.2008.043, 2008. 
Berger, M. and Zimmermann, S. (Eds.): P1.03 – In-line-Monitoring der Elektrolyt- und Harnstoffkonzentration in extrakorporalen Kreisläufen zur Individualisierung der Nierenersatztherapie, 13. Dresdner Sensor-Symposium, https://doi.org/10.5162/13dss2017, Dresden, Germany, 2017. 
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Short summary
In this paper we investigate an in-line concept for continuous monitoring of sodium, potassium, calcium and urea concentrations in blood serum using ion-selective electrodes. This concept is evaluated in a preclinical study with human packed red blood cells as a test medium. It has been shown that the electrolytes can be well monitored. In addition, we present the first measurements with ion-sensitive field-effect transistors in a miniaturized sensor assembly using a novel readout electronics.