Articles | Volume 8, issue 1
https://doi.org/10.5194/jsss-8-215-2019
https://doi.org/10.5194/jsss-8-215-2019
Regular research article
 | 
21 May 2019
Regular research article |  | 21 May 2019

Optical and impedimetric study of genetically modified cells for diclofenac sensing

Margarita Guenther, Falko Altenkirch, Kai Ostermann, Gerhard Rödel, Ingo Tobehn-Steinhäuser, Steffen Herbst, Stefan Görlandt, and Gerald Gerlach

Related authors

Hydrogel-based piezoresistive sensor for the detection of ethanol
Jan Erfkamp, Margarita Guenther, and Gerald Gerlach
J. Sens. Sens. Syst., 7, 219–226, https://doi.org/10.5194/jsss-7-219-2018,https://doi.org/10.5194/jsss-7-219-2018, 2018
Short summary

Related subject area

Sensor principles and phenomena: Chemical and biochemical sensors
Development of electrochemical sensors based on silver nanoparticles electrodeposited on gold screen-printed electrodes: application to nitrate trace analysis in water
Najib Ben Messaoud, Marília Barreiros dos Santos, Begoña Espiña, and Raquel Barbosa Queirós
J. Sens. Sens. Syst., 13, 135–145, https://doi.org/10.5194/jsss-13-135-2024,https://doi.org/10.5194/jsss-13-135-2024, 2024
Short summary
Chemical hydrogel sensors based on the bimorph effect with short response time
Stefan Schreiber, Nadja Steinke, and Gerald Gerlach
J. Sens. Sens. Syst., 12, 141–146, https://doi.org/10.5194/jsss-12-141-2023,https://doi.org/10.5194/jsss-12-141-2023, 2023
Short summary
Design of a dual electrochemical quartz crystal microbalance with dissipation monitoring
Rafael Ecker, Nikolaus Doppelhammer, Bernhard Jakoby, and Erwin Konrad Reichel
J. Sens. Sens. Syst., 11, 21–28, https://doi.org/10.5194/jsss-11-21-2022,https://doi.org/10.5194/jsss-11-21-2022, 2022
Short summary
Surface plasmon assisted toxic chemical NO2 gas sensor by Au ∕ ZnO functional thin films
Ravinder Gaur, Himanshu Mohan Padhy, and Manikandan Elayaperumal
J. Sens. Sens. Syst., 10, 163–169, https://doi.org/10.5194/jsss-10-163-2021,https://doi.org/10.5194/jsss-10-163-2021, 2021
Short summary
Studies on porosity in poly(N-isopropylacrylamide) hydrogels for fast-responsive piezoresistive microsensors
Daniela Franke and Gerald Gerlach
J. Sens. Sens. Syst., 10, 93–100, https://doi.org/10.5194/jsss-10-93-2021,https://doi.org/10.5194/jsss-10-93-2021, 2021

Cited articles

Adeniran, A., Sherer, M., and Tyo, K. E. J.: Yeast-based biosensors: Design and applications, FEMS Yeast Res., 15, 1–15, 2015. 
Altintas, Z., Guerreiro, A., Piletsky S. A., and Tothill, I. E.: NanoMIP based optical sensor for pharmaceuticals monitoring, Sensor Actuat. B-Chem., 213, 305–313, https://doi.org/10.1016/j.snb.2015.02.043, 2015. 
Arroyo-López, F. N., Orli, S., Querol, A., and Barrio, E.: Effects of temperature, pH and sugar concentration on the growth parameters of Saccharomyces cerevisiae, S. kudriavzevii and their interspecific hybrid, Int. J. Food Microbiol., 131, 120–127, https://doi.org/10.1016/j.ijfoodmicro.2009.01.035, 2009. 
Borga, O. and Borga, B.: Serum protein binding of nonsteroidal anti-inflammatory drugs: a comparative study, J. Pharmacokinet. Biop., 25, 63–77, 1997. 
Brennan, E., Futvoie, P., Cassidy, J., and Schazmann, B.: An ionic liquid-based sensor for diclofenac determination in water, Int. J. Environ. An. Ch., 97, 588–596, https://doi.org/10.1080/03067319.2017.1333607, 2017. 
Download
Short summary
In this work, genetically modified cells of the yeast Saccharomyces cerevisiae BY4741 were confined in a four-chamber microfluidic cell, providing an optical monitoring of the cell behaviour and their supply with the nutrients. The measurements of the time-dependent fluorescence intensity were performed with different concentrations of the drug diclofenac, and the sensitivity of yeast cells to diclofenac was demonstrated. Cell viability was monitored by simultaneous impedance recording.