Articles | Volume 13, issue 2
https://doi.org/10.5194/jsss-13-245-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jsss-13-245-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
A portable biosensor for simultaneous diagnosis of TNF-α and IL-1β in saliva biomarkers using twin electronic devices
Majid Monajjemi
CORRESPONDING AUTHOR
Department of Chemical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Fatemeh Mollaamin
Department of Biomedical Engineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Türkiye
Motahareh Dehghandar
Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Sara Shahriari
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Parisa Latifi
Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Samira Mohammadi
Department of Chemical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Related subject area
Measurement systems: Sensor signal processing and electronics
Extraction of nanometer-scale displacements from noisy signals at frequencies down to 1 mHz obtained by differential laser Doppler vibrometry
Simple in-system control of microphone sensitivities in an array
Wireless surface acoustic wave resonator sensors: fast Fourier transform, empirical mode decomposition or wavelets for the frequency estimation in one shot?
Ultrasonic measurement setup for monitoring pre-thawing stages of food
Digital twin concepts for linking live sensor data with real-time models
Assisting the automated analysis of chemical–analytical measurements in spirits using validated algorithms and an intuitive user interface
Simulation-based investigation of the metrological interface structural resolution capability of X-ray computed tomography scanners
Design of a CMOS memristor emulator-based, self-adaptive spiking analog-to-digital data conversion as the lowest level of a self-x hierarchy
Smart in-cylinder pressure sensor for closed-loop combustion control
Efficient transient testing procedure using a novel experience replay particle swarm optimizer for THD-based robust design and optimization of self-X sensory electronics in industry 4.0
Intelligent fault detection of electrical assemblies using hierarchical convolutional networks for supporting automatic optical inspection systems
Measurement uncertainty analysis of field-programmable gate-array-based, real-time signal processing for ultrasound flow imaging
Compilation of training datasets for use of convolutional neural networks supporting automatic inspection processes in industry 4.0 based electronic manufacturing
Employing correlation for wireless components and device characterization in reverberation chambers
Impedance model for a high-temperature ceramic humidity sensor
Non-destructive testing of arbitrarily shaped refractive objects with millimetre-wave synthetic aperture radar imaging
Determining the dimension of subsurface defects by active infrared thermography – experimental research
Inverse calculation of strain profiles from ETDR measurements using artificial neural networks
An ultra-low noise capacitance to voltage converter for sensor applications in 0.35 µm CMOS
Development of a non-contact torque transducer based on the laser speckle contrast method
Development of a chopper charge amplifier for measuring the cavity pressure inside injection moulding tools and signal optimisation with a Kalman filter
Optimized mixed-domain signal synthesis for broadband impedance spectroscopy measurements on lithium ion cells for automotive applications
High-accuracy current measurement with low-cost shunts by means of dynamic error correction
A compact readout platform for spectral-optical sensors
High-speed camera-based measurement system for aeroacoustic investigations
Shutter-less calibration of uncooled infrared cameras
A novel approach for detecting HMDSO poisoning of metal oxide gas sensors and improving their stability by temperature cycled operation
Micro- and nanocoordinate measurements of micro-parts with 3-D tunnelling current probing
An electrical characterisation system for the real-time acquisition of multiple independent sensing parameters from organic thin film transistors
Piezoelectric transceiver matching for multiple frequencies
Metal oxide semiconductor gas sensor self-test using Fourier-based impedance spectroscopy
Work area monitoring in dynamic environments using multiple auto-aligning 3-D sensors
Principal component analysis for fast and automated thermographic inspection of internal structures in sandwich parts
Near-field interrogation of SAW resonators on rotating machinery
Magnetic properties of CHAMP and their effects on in-orbit calibration
Dhyan Kohlmann, Marvin Schewe, Hendrik Wulfmeier, Christian Rembe, and Holger Fritze
J. Sens. Sens. Syst., 13, 167–177, https://doi.org/10.5194/jsss-13-167-2024, https://doi.org/10.5194/jsss-13-167-2024, 2024
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A very small, anharmonic but periodic signal is separated from a noise background that is orders of magnitude larger than the pure signal. The approach consists of a sequence of filters and transformations and is demonstrated on an interferometric measurement of the high-temperature chemical expansion of a thin film, containing heat haze, thermal length drift, and parasitic vibrations. The displacement is 38 % larger and the uncertainty 35 % lower than when evaluated with previous approaches.
Artem Ivanov
J. Sens. Sens. Syst., 13, 81–88, https://doi.org/10.5194/jsss-13-81-2024, https://doi.org/10.5194/jsss-13-81-2024, 2024
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The presented approach allows users to perform measurements of microphone responses directly in the array using the internal hardware and so to characterize the whole signal chain of microphone–preamplifier–ADC. The measurements do not need special equipment and can be carried out in ordinary reverberant locations. A loudspeaker driven by a voltage pulse is used to produce a sound wave with a short first wavefront. Processing only this wavefront suppresses reflected waves that arrive later.
Angel Scipioni, Pascal Rischette, and Agnès Santori
J. Sens. Sens. Syst., 12, 247–260, https://doi.org/10.5194/jsss-12-247-2023, https://doi.org/10.5194/jsss-12-247-2023, 2023
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Many applications which measure physical quantities rely on wireless surface acoustic wave sensors. The accuracy of this sensor depends directly on the measurement of its main frequency. This paper aims to compare three methods for this measurement in one shot: fast Fourier transform, discrete wavelet transform, and empirical mode decomposition. Results show that the choice of the method is conditioned by the disturbance level and that the wavelet method is the best way for harsh environments.
Ruchi Jha, Walter Lang, and Reiner Jedermann
J. Sens. Sens. Syst., 12, 133–139, https://doi.org/10.5194/jsss-12-133-2023, https://doi.org/10.5194/jsss-12-133-2023, 2023
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In order to save time and avoid overheating of food during unfreezing, the study of ice content can be very useful. The aim of the research is to design an ultrasound-based sensor system that is able to comment on the content of ice in the sample food product. Some sample food products are tested, and the observations and challenges concerning the same are mentioned in the research paper.
Reiner Jedermann, Kunal Singh, Walter Lang, and Pramod Mahajan
J. Sens. Sens. Syst., 12, 111–121, https://doi.org/10.5194/jsss-12-111-2023, https://doi.org/10.5194/jsss-12-111-2023, 2023
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Mathematical models are often required to process sensor data in a digital twin platform. The translation of models to an updateable format enables predicting hidden states of the physical object, which are not directly measurable. The linking of different models is demonstrated by data from field tests on fruit transportation in refrigerated containers. We programmed a streaming platform that enables easy integration of such updatable models with only a few milliseconds of processing overhead.
Andreas T. Grasskamp, Satnam Singh, Helen Haug, and Tilman Sauerwald
J. Sens. Sens. Syst., 12, 93–101, https://doi.org/10.5194/jsss-12-93-2023, https://doi.org/10.5194/jsss-12-93-2023, 2023
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In this work, we have developed and validated a semi-automatic approach that greatly reduces the amount of interaction and effort needed for analyzing samples via gas chromatography–mass spectrometry. Further, unlike many other approaches, our developed tool is accessible to the novice and does not require any programming experience. Using whisky as an example substance, we show how the analysis method compares to conventional software, and we validate our approach against that.
Matthias Busch and Tino Hausotte
J. Sens. Sens. Syst., 12, 1–8, https://doi.org/10.5194/jsss-12-1-2023, https://doi.org/10.5194/jsss-12-1-2023, 2023
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The paper presents a specimen and evaluation method for interface structural resolution testing of X-ray computed tomography systems based on CT simulations. The geometry is oriented to the norms of image quality investigation. The evaluation is based on profile lines of the cross-sectional images that pass through the boreholes. All statements on resolution refer to the entire measurement chain and, thus, in addition to the reconstruction algorithm also to the surface determination method used.
Hamam Abd and Andreas König
J. Sens. Sens. Syst., 11, 233–262, https://doi.org/10.5194/jsss-11-233-2022, https://doi.org/10.5194/jsss-11-233-2022, 2022
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We pursue a promising novel self-adaptive spiking neural analog-to-digital data conversion (SN-ADC) design that uses spike time to carry information. Thus, SN-ADC can be effectively translated to aggressive new technologies to implement reliable advanced sensory electronic systems. The SN-ADC supports self-x (self-calibration, self-optimization, and self-healing) and machine learning required for the internet of things and Industry 4.0 and is based on a self-adaptive CMOS memristor.
Dennis Vollberg, Peter Gibson, Günter Schultes, Hans-Werner Groh, and Thomas Heinze
J. Sens. Sens. Syst., 11, 1–13, https://doi.org/10.5194/jsss-11-1-2022, https://doi.org/10.5194/jsss-11-1-2022, 2022
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We developed a smart in-cylinder pressure sensor for closed-loop combustion control. The sensor concept is based on a robust and reliable steel membrane equipped with highly strain-sensitive and temperature-stable thin films. The sensor system is complemented by a smart electronics allowing real-time data processing for calculation of different combustion parameters. The data are utilized to control the igniting timing of a spark plug for efficient operation of a combustion engine.
Qummar Zaman, Senan Alraho, and Andreas König
J. Sens. Sens. Syst., 10, 193–206, https://doi.org/10.5194/jsss-10-193-2021, https://doi.org/10.5194/jsss-10-193-2021, 2021
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A novel experience replay particle swarm optimization algorithm is presented and successfully deployed to improve the optimization performance for reconfigurable analog integrated circuits of industry 4.0. An optimization approach is introduced that relied on THD-based indirect measurement method that varies from the traditional calibration approach. Instead, the proposed calibration methodology optimizes all characteristics of the reconfigurable amplifier at once.
Alida Ilse Maria Schwebig and Rainer Tutsch
J. Sens. Sens. Syst., 9, 363–374, https://doi.org/10.5194/jsss-9-363-2020, https://doi.org/10.5194/jsss-9-363-2020, 2020
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In order to further increase the performance of neural networks in the field of optical quality assurance of soldered joints, a hierarchical classifier can be used instead of a single network. The global expansion of the classifier enables the inspection task to be distributed over several subnetworks, which results in higher accuracy. Since the individual sub-models only concentrate on the identification of certain characteristics, categorical problems can be solved more effectively.
Richard Nauber, Lars Büttner, and Jürgen Czarske
J. Sens. Sens. Syst., 9, 227–238, https://doi.org/10.5194/jsss-9-227-2020, https://doi.org/10.5194/jsss-9-227-2020, 2020
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To improve the energy efficiency of industrial processes, such as continuous steel casting, lab-scale experiments with liquid metals are performed. We present an ultrasound Doppler signal process for multiplane, high-frame-rate flow imaging. We achieve real-time operations with an efficient implementation in a field-programmable gate array (FPGA). We analyze the contributions to the uncertainty of the velocity measurement and relate it to its fundamental limit.
Alida Ilse Maria Schwebig and Rainer Tutsch
J. Sens. Sens. Syst., 9, 167–178, https://doi.org/10.5194/jsss-9-167-2020, https://doi.org/10.5194/jsss-9-167-2020, 2020
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This article presents a classification concept based on deep learning as an additional optical test method for real-time visualization and analysis of electrical assemblies in the production environment. For this purpose, a neural convolutional network is used to identify the quality of the solder joint of surface-mounted chip components in the inspection images. The concept can be used to increase the detection performance of the solder joint inspection systems.
Christoph Cammin, Dmytro Krush, Ralf Heynicke, and Gerd Scholl
J. Sens. Sens. Syst., 8, 185–194, https://doi.org/10.5194/jsss-8-185-2019, https://doi.org/10.5194/jsss-8-185-2019, 2019
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Reverberation chambers are well-proven test environments for RF measurements. Typically, mean values are taken from the measurements to characterize the equipment under test. In the novel approach presented in this paper, the correlation of measured sample sequences is utilized to detect deviations, in particular of the radiation characteristics, from reference equipment.
Henrik Lensch, Manuel Bastuck, Tobias Baur, Andreas Schütze, and Tilman Sauerwald
J. Sens. Sens. Syst., 8, 161–169, https://doi.org/10.5194/jsss-8-161-2019, https://doi.org/10.5194/jsss-8-161-2019, 2019
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The measurement of humidity in industrial applications is still an important research issue. Especially under rough operation conditions the current humidity sensor comes to its limitations. To this end, we are developing an integrated sensor system using a metal oxide sensor with impedance spectroscopy as multi-signal generation allowing the discrimination of humidity and reducing gases. The submitted paper focuses on the modeling of the humidity-dependent aspects of impedance.
Ingrid Ullmann, Julian Adametz, Daniel Oppelt, Andreas Benedikter, and Martin Vossiek
J. Sens. Sens. Syst., 7, 309–317, https://doi.org/10.5194/jsss-7-309-2018, https://doi.org/10.5194/jsss-7-309-2018, 2018
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Millimetre-wave radar is an emerging technique for non-destructive testing: it is less costly than X-rays and has no ionizing radiation. Compared to ultrasound it does not require the device under test to be immersed in water. This article presents methods for high-resolution millimetre-wave radar imaging without a priori knowledge of the object's shape. A polymer device with simulated material defects is examined, which could be depicted precisely.
Slawomir Grys
J. Sens. Sens. Syst., 7, 153–160, https://doi.org/10.5194/jsss-7-153-2018, https://doi.org/10.5194/jsss-7-153-2018, 2018
Robin Höhne, Pawel Kostka, and Niels Modler
J. Sens. Sens. Syst., 6, 389–394, https://doi.org/10.5194/jsss-6-389-2017, https://doi.org/10.5194/jsss-6-389-2017, 2017
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This paper focuses on a novel carbon fibre sensor technology that exploits the low-cost and low-energy electrical reflectometry method for a spatially resolved strain measurement. The application of artificial neural networks for mapping the measured electrical signal to the existing strain profile is demonstrated. The potential and current limits are highlighted. The sensor is a promising part for the next generation of light-weight structures with operando health monitoring systems.
Alexander Utz, Christian Walk, Norbert Haas, Tatjana Fedtschenko, Alexander Stanitzki, Mir Mokhtari, Michael Görtz, Michael Kraft, and Rainer Kokozinski
J. Sens. Sens. Syst., 6, 285–301, https://doi.org/10.5194/jsss-6-285-2017, https://doi.org/10.5194/jsss-6-285-2017, 2017
Alberto Garinei and Roberto Marsili
J. Sens. Sens. Syst., 6, 253–258, https://doi.org/10.5194/jsss-6-253-2017, https://doi.org/10.5194/jsss-6-253-2017, 2017
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When a torque measurement is required, torque transducers show many drawbacks during their use: the usual limits are the need for contact and the effects on shaft line parameters. A new approach is proposed in this work: a non-contact torque meter for a machine shaft has been developed, based on a laser speckle contrast method. It carries out torque measurements evaluating the torsional displacement between two distinct sections of the shaft, through the monitoring of their roughness.
Manuel Schneider, Alexander Jahn, Norbert Greifzu, and Norbert Fränzel
J. Sens. Sens. Syst., 6, 199–210, https://doi.org/10.5194/jsss-6-199-2017, https://doi.org/10.5194/jsss-6-199-2017, 2017
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This article describes a chopper amplifier which has been specially developed for piezoelectric pressure sensors. It is shown that the amplifier provides good results for pressure measurement in injection moulds. A special feature of this work is the signal optimisation through the use of a Kalman filter.
Peter Haußmann and Joachim Melbert
J. Sens. Sens. Syst., 6, 65–76, https://doi.org/10.5194/jsss-6-65-2017, https://doi.org/10.5194/jsss-6-65-2017, 2017
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A method to generate broadband waveforms with low peak-to-peak amplitude based on distinct frequency domain profiles is presented, which includes random phase variation and numerical optimization. The peak-to-peak amplitude can be reduced by 71 % compared to zero-phase pulses with equal frequency domain characteristics. Used as excitation signals for impedance spectroscopy, the waveforms yield good results at significantly reduced measurement duration compared to established measurement methods.
Patrick Weßkamp and Joachim Melbert
J. Sens. Sens. Syst., 5, 389–400, https://doi.org/10.5194/jsss-5-389-2016, https://doi.org/10.5194/jsss-5-389-2016, 2016
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Measurement of electrical current is important for many scientific and industrial applications. Often shunt resistors are used. However, thermal effects due to self-heating and ambient temperature variation limit the achievable accuracy.
In this work, a dynamic compensation method is presented which takes static and dynamic temperature drift effects into account. It significantly reduces the remaining measurement errors. The approach can also be used to improve existing measurement systems.
Roland Wuchrer, Sabrina Amrehn, Luhao Liu, Thorsten Wagner, and Thomas Härtling
J. Sens. Sens. Syst., 5, 157–163, https://doi.org/10.5194/jsss-5-157-2016, https://doi.org/10.5194/jsss-5-157-2016, 2016
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The continuous monitoring of industrial and environmental processes is becoming an increasingly important aspect with both economic and societal impact. To realize this task, spectral-optical sensors with their outstanding properties in terms of sensitivity and reliability are a potential solution. However, for exploiting these sensors in a cost- and energy-efficient sensing system, a miniaturized readout unit is needed. Here we present a card-size, inexpensive, and robust readout electronics.
Johannes Gürtler, Daniel Haufe, Anita Schulz, Friedrich Bake, Lars Enghardt, Jürgen Czarske, and Andreas Fischer
J. Sens. Sens. Syst., 5, 125–136, https://doi.org/10.5194/jsss-5-125-2016, https://doi.org/10.5194/jsss-5-125-2016, 2016
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The interaction of sound and flow enables an efficient noise damping. Understanding this aeroacoustic damping phenomenon requires simultaneous measurement of flow and sound fields. Using a high-speed CMOS camera, two-component flow velocity measurements are performed in a three-dimensional region of interest. The sensor system can simultaneously capture sound and turbulent flow velocity oscillations. The presented measurements reveal that the sound energy is transferred into flow energy.
A. Tempelhahn, H. Budzier, V. Krause, and G. Gerlach
J. Sens. Sens. Syst., 5, 9–16, https://doi.org/10.5194/jsss-5-9-2016, https://doi.org/10.5194/jsss-5-9-2016, 2016
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Infrared cameras based on microbolometer focal plane arrays (FPAs) are the most widely used cameras in thermography. For acceptable measurement uncertainty values, the disturbing influences of changing ambient temperature have to be considered. We propose a TEC-less and shutter-less correction approach based on additional temperature measurements inside the IR camera. The effects on the pixel responsivity and offset voltage are considered separately.
M. Schüler, T. Sauerwald, and A. Schütze
J. Sens. Sens. Syst., 4, 305–311, https://doi.org/10.5194/jsss-4-305-2015, https://doi.org/10.5194/jsss-4-305-2015, 2015
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We study the effect of HMDSO vapor on an SnO2-based gas sensor in temperature cycled operation (TCO). The poisoning can be quantified at early stages with a resolution of ±85 ppm*min using TCO. This approach provides a simple method for early detection of HMDSO poisoning.
The stability of gas discrimination by linear discriminant analysis (LDA) can be improved using normalization, which in turn facilitates a more accurate determination of the poisoning state by hierarchical LDA discrimination.
A. Schuler, T. Hausotte, and Z. Sun
J. Sens. Sens. Syst., 4, 199–208, https://doi.org/10.5194/jsss-4-199-2015, https://doi.org/10.5194/jsss-4-199-2015, 2015
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Measurement tasks of modern micro- and nanometrology with decreasing structure sizes and rising aspect ratios require nanometre-resolving 3-D capable sensors. A 3-D probing system based on electrical interaction is presented which is operated on a nanopositioning system NMM-1. New 3-D measurement procedures for the probing system as well as for micrometrology measurement tasks in general are shown.
A. Dragoneas, L. Hague, and M. Grell
J. Sens. Sens. Syst., 4, 169–177, https://doi.org/10.5194/jsss-4-169-2015, https://doi.org/10.5194/jsss-4-169-2015, 2015
A. Ens and L. M. Reindl
J. Sens. Sens. Syst., 4, 9–16, https://doi.org/10.5194/jsss-4-9-2015, https://doi.org/10.5194/jsss-4-9-2015, 2015
M. Schüler, T. Sauerwald, and A. Schütze
J. Sens. Sens. Syst., 3, 213–221, https://doi.org/10.5194/jsss-3-213-2014, https://doi.org/10.5194/jsss-3-213-2014, 2014
Y. Wang, D. Ewert, T. Meisen, D. Schilberg, and S. Jeschke
J. Sens. Sens. Syst., 3, 113–120, https://doi.org/10.5194/jsss-3-113-2014, https://doi.org/10.5194/jsss-3-113-2014, 2014
D. Griefahn, J. Wollnack, and W. Hintze
J. Sens. Sens. Syst., 3, 105–111, https://doi.org/10.5194/jsss-3-105-2014, https://doi.org/10.5194/jsss-3-105-2014, 2014
J.-M. Boccard, P. Katus, R. Renevier, L. M. Reindl, and J.-M. Friedt
J. Sens. Sens. Syst., 2, 147–156, https://doi.org/10.5194/jsss-2-147-2013, https://doi.org/10.5194/jsss-2-147-2013, 2013
H. Lühr, F. Yin, and R. Bock
J. Sens. Sens. Syst., 2, 9–17, https://doi.org/10.5194/jsss-2-9-2013, https://doi.org/10.5194/jsss-2-9-2013, 2013
Cited articles
Abayomi, L. A., Terry, L. A., White, S. F., and Warner, P. J.: Development of a disposable pyruvate biosensor to determine pungency in onions (Allium cepa L.), Biosens. Bioelectron., 21, 2176–2179, https://doi.org/10.1016/j.bios.2005.10.024, 2006.
Arif, S., Qudsia, S., Urooj, S., Chaudry, N., Arshad, A., and Andleeb, S.: Blueprint of quartz crystal microbalance biosensor for early detection of breast cancer through salivary autoantibodies against ATP6AP1, Biosens. Bioelectron., 65, 62–70, https://doi.org/10.1016/j.bios.2014.09.088, 2015.
Andrusier, N., Nussinov, R., and Wolfson, H. J.: FireDock: Fast Interaction Refinement in Molecular Docking, Proteins, 69, 139–159, https://doi.org/10.1002/prot.21495, 2007.
Andrusier, N., Mashiach, E., Nussinov, R., and Wolfson, H. J.: Principles of flexible protein–protein docking, Proteins, 73, 271–289, https://doi.org/10.1002/prot.22170, 2008.
Aroonyadet, N., Wang, X., Song, Y., Chen, H., Cote, R. J., Thompson, M. E., Datar, R. H., and Zhou, C.: Highly Scalable, Uniform, and Sensitive Biosensors Based on Top-Down Indium Oxide Nanoribbons and Electronic Enzyme-Linked Immunosorbent Assay, Nano Lett., 15, 1943–1951, https://doi.org/10.1021/nl5047889, 2015.
Asatsuma, M., Ito, S., Watanabe, M., Takeishi, H., Nomura, S., Wada, Y., Nakano, M., Gejyo, F., and Igarashi, A.: Matrix metalloproteinase 9 (MMP-9) gene polymorphism, Clin. Chim. Acta, 345, 99–104, https://doi.org/10.1016/j.cccn.2004.03.006, 2004.
Aspermair, P., Mishyn, V., Bintinger, J., Happy, H., Bagga, K., Subramanian, P., Knoll, W., Boukherroub, R., and Szunerits, S.: Reduced graphene oxide–based field effect transistors for the detection of E7 protein of human papillomavirus in saliva, Anal. Bioanal. Chem., 413, 779–787, https://doi.org/10.1007/s00216-020-02879-z, 2021.
Aydın, M., Aydın, E. B., and Sezgintürk, M. K.: A highly selective electrochemical immunosensor based on conductive carbon black and star PGMA polymer composite material for IL-8 biomarker detection in human serum and saliva, Biosens. Bioelectron., 117, 720–728, https://doi.org/10.1016/j.bios.2018.07.010, 2018.
Bahri, M., A. Baraket, N., Zine, M. B., Ali, J., Bausells, A., and Errachid, T.: Capacitance electrochemical biosensor based on silicon nitride transducer for TNF-α cytokine detection in artificial human saliva: Heart failure (HF), Talanta, 209, 120501, https://doi.org/10.1016/j.talanta.2019.120501, 2020.
Barhoumi, L., Baraket, A., Bellagambi, F. G., Karanasiou, G. S., Ali, M. B., Fotiadis, D. I., Bausells, J., Zine, N., Sigaud, M., and Errachid, A.: A novel chronoamperometric immunosensor for rapid detection of TNF-α in human saliva, Sensor. Actuat. B-Chem., 266, 477–484, https://doi.org/10.1016/j.snb.2018.03.135, 2018.
Bayraktaroglu, B., Leedy, K., and Neidhard, R.: Highfrequency ZnO thin-film transistors on Si substrates, IEEE Electr. Device L., 30, 946–948, 2009.
Bellagambi, F. G., Petersen, C., Salvo, P., Ghimenti, S., Franzini, M., Biagini, D., Hangouët, M., Trivella, M. G., Di Francesco, F., Paolicchi, A., Errachid, A., Fuoco, R., and Lomonaco, T.: Determination and stability of N-terminal pro-brain natriuretic peptide in saliva samples for monitoring heart failure, Sci. Rep., 11, 13088, https://doi.org/10.1038/s41598-021-92488-2, 2021.
Botelho, C. N., Falcão, S. S., Soares, R.-E. P., Pereira, S. R., de Menezes, A. S., Kubota, L. T., Damos, F. S., and Luz, R. C. S.: Evaluation of a photoelectrochemical platform based on strontium titanate, sulfur doped carbon nitride and palladium nanoparticles for detection of SARS-CoV-2 spike glycoprotein S1, Biosensors and Bioelectronics: X, 11, 100167, https://doi.org/10.1016/j.biosx.2022.100167, 2022.
Buchan, E., Kelleher, L., Clancy, M., Rickard, J. J. S., and Oppenheimer, P. G.: Spectroscopic molecular-fingerprint profiling of saliva, Anal. Chim. Acta, 1185, 339074, https://doi.org/10.1016/j.aca.2021.339074, 2021.
Burtscher, B., Urbina, P. A. M., Diacci, C., Borghi, S., Pinti, M., Cossarizza, A., Salvarani, C., Berggren, M., Biscarini, F., Simon, D. T., and Bortolotti, C. A.: Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors, Adv. Healthc. Mater., 10, 2100955, https://doi.org/10.1002/adhm.202100955, 2021.
CHARMM (Chemistry at HARvard Macromolecular Mechanics): https://www.academiccharmm.org/, last access: 22 November 2024.
Choi, Y. E., Kwak, J. W., and Park, J. W.: Nanotechnology for early cancer detection, Sensors, 10, 428–455, https://doi.org/10.3390/s100100428, 2010.
Christodoulides, N., Mohanty, S., Miller, C. S., Langub, M. C., Floriano, P. N., Dharshan, P., Ali, M., Bernard, F., Romanovicz, B. D., Anslyn, E., Fox, P. C., and McDevitt, J. T.: Application of microchip assay system for the measurement of C-reactive protein in human saliva, Lab Chip, 5, 261–269, 2005.
Chu, P. S., Nakamoto, N., Ebinuma, H., Usui, S., Saeki, K., and Matsumoto, A.: C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice, Hepatology, 58, 337–350, https://doi.org/10.1002/hep.26351, 2013.
Costa, P. P., Trevisan, G. L., Macedo, G. O., Palioto, D. B., Souza, S. L. S., Grisi, M. F. M., Novaes Jr., A. B., and Taba Jr., M.: Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes, J. Periodontol., 81, 384, https://doi.org/10.1902/jop.2009.090510, 2010.
Cunningham, B. T. and Laing, L. G.: Advantages and application of label-free detection assays in drug screening, Expert Opin. Drug Dis., 3, 891–901, https://doi.org/10.1517/17460441.3.8.891, 2008.
Dikova, V., Jantus-Lewintre, E., and Bagan, J.: Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma, J. Clin. Med., 10, 1658, https://doi.org/10.3390/jcm10081658, 2021.
Dharmalingam, M. and Yamasandhi, P. G.: Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus, Indian Journal of Endocrinology and Metabolism, 22, 421–428, https://doi.org/10.4103/ijem.IJEM_585_17, 2018.
Erdem, A., Senturk, H., Yildiz, E., and Maral, M.: Amperometric immunosensor developed for sensitive detection of SARS-CoV-2 spike S1 protein in combined with portable device, Talanta, 244, 123422, https://doi.org/10.1016/j.talanta.2022.123422, 2022.
Fleischhaker, F., Wloka, V., and Hennig, I.: ZnO based field-effect transistors (FETs): Solution-processable at low temperatures on flexible substrates, J. Mater. Chem., 20, 6622–6625, 2010.
Fortunato, E., Barquinha, P., and Martins, R.: Oxide semiconductor thin-film transistors: A review of recent advances, Adv. Mater., 24, 2945–2986, 2012.
Ghalandari, B., Monajjemi, M., and Mollaamin, F.: Theoretical investigation of carbon nanotube binding to DNA in view of drug delivery, J. Comput. Theor. Nanos., 8, 1212–1219, https://doi.org/10.1166/jctn.2011.1801, 2011.
Gough, P. and Myles, I. A.: Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects, Front. Immunol., 11, 585880, https://doi.org/10.3389/fimmu.2020.585880, 2020.
Gravallese, E. M. and Monach, P. A.: 94 - The rheumatoid joint: Synovitis and tissue destruction, Rheumatology (Sixth Edition), 1, 768–784, https://doi.org/10.1016/B978-0-323-09138-1.00094-2, 2015.
Guan, W.-J., Li, Y., Chen, Y. Q., Zhang, X. B., and Hu, G. Q.: Glucose biosensor based on multi-wall carbon nanotubes and screen printed carbon electrodes, Biosens. Bioelectron., 21, 508–512, 2005.
Guerreiro, J. R. L., Frederiksen, M., Bochenkov, V. E., De Freitas, V., and Sales, M. G. F.: Multifunctional biosensor based on localized surface plasmon resonance for monitoring small molecule–protein interaction, ACS Nano, 8, 7958–7967, https://doi.org/10.1021/nn501962y, 2014.
Guerrero, S., Agüí, L., Yáñez-Sedeño, P., and Pingarrón, J. M.: Design of electrochemical immunosensors using electro-click chemistry. Application to the detection of IL-1β cytokine in saliva, Bioelectrochemistry, 133, 107484, https://doi.org/10.1016/j.bioelechem.2020.107484, 2020.
Gug, I. T., Tertis, M., Hosu, O., and Cristea, C.: Salivary biomarkers detection: Analytical and immunological methods overview, TrAC-Trend. Anal. Chem., 113, 301–316, 2019.
Hagen, J., Kim, S., Bayraktaroglu, B., Leedy, K., Chavez, J., Kelley-Loughnane, N., Naik, R., and Stone, M.: Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin with Current Modulation, Sensors, 11, 6645–6655, https://doi.org/10.3390/s110706645, 2011.
Heiney, P. A., Grüneberg, K., Fang, J., Dulcey, C., and Shashidhar, R.: Structure and Growth of Chromophore-Functionalized (3-Aminopropyl)triethoxysilane Self-Assembled on Silicon, Langmuir, 16, 2651–2657, 2000.
Heir, R. and Stellwagen, D.: TNF-Mediated Homeostatic Synaptic Plasticity: From in vitro to in vivo Models, Front. Cell. Neurosci., 14, 565841, https://doi.org/10.3389/fncel.2020.565841, 2021.
Hermanson, G.: Bioconjugate Techniques, Elsevier, New, York, 2nd edn., eBook ISBN: 9780080568720, 2010.
Hsiao, Y.-C., Chu, L. J., Chen, Y.-T., Chi, L.-M., Chien, K.-Y., Chiang, W.-F., Chang, Y.-T., Chen, S.-F., Wang, W.-S., Chuang, Y.-N., Lin, S.-Y., Chien, C.-Y., Chang, K.-P., Chang, Y.-S., and Yu, J.-S.: Variability Assessment of 90 Salivary Proteins in Intraday and Interday Samples from Healthy Donors by Multiple Reaction Monitoring-Mass Spectrometry, Proteomic. Clin. Appl., 12, 1700039, https://doi.org/10.1002/prca.201700039, 2018.
Hu, S., Loo, J. A., and Wong, D. T.: Human saliva proteome analysis, Ann. NY Acad. Sci., 1098, 323, https://doi.org/10.1196/annals.1384.015, 2007.
Hypercube, Inc.: HyperChem, http://www.hypercubeusa.com/, last access: 22 November 2024.
Joe, C., Lee, B. H., Kim, S. H., Kod, Y., and Gu, M. B.: Aptamer duo-based portable electrochemical biosensors for early diagnosis of periodontal disease, Biosens. Bioelectron., 199, 113884, https://doi.org/10.1016/j.bios.2021.113884, 2022.
Kakino, S., Ohki, T., Nakayama, H., Yuan, X., Otabe, S., Hashinaga, T., Wada, N., Kurita, Y., Tanaka, K., Hara, K., Soejima, E., Tajiri, Y., and Yamada, K.: Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model, Horm. Metab. Res., 50, 80–87, https://doi.org/10.1055/s-0043-118666, 2018.
Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K., and Kasuga, M.: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, The Journal of Clinical Investigation, 116, 1494–1505, https://doi.org/10.1172/JCI26498, 2006.
Karaboga, M. N. S. and Sezgintürk, M. K.: A nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1/Park7 in cerebrospinal fluid and saliva, Bioelectrochemistry, 138, 107734, https://doi.org/10.1016/j.bioelechem.2020.107734, 2021.
Karaman, C., Yola, B. B., Karaman, O., Atar, N., Polat, I., and Yola, M. L.: Sensitive sandwich-type electrochemical SARS-CoV2 nucleocapsid protein immunosensor, Microchim. Acta, 188, 425, https://doi.org/10.1007/s00604-021-05092-6, 2021.
Kaushik, R., Yeltiwar, R. K., and Pushpanshu, K.: Salivary interleukin-1β levels in patients with chronic periodontitis before and after periodontal phase I therapy and healthy controls: a case-control study, J. Periodontol., 82, 1353–1359, https://doi.org/10.1902/jop.2011.100472, 2011.
Khaleghian, M., Zahmatkesh, M., Mollaamin, F., and Monajjemi, M.: Investigation of solvent effects on armchair single-walled carbon nanotubes: A QM/MD study, Fuller. Nanotub. Car. N., 19, 251–261, https://doi.org/10.1080/15363831003721757, 2011.
Khalili Hadad, B., Mollaamin, F., and Monajjemi, M.: Biophysical chemistry of macrocycles for drug delivery: A theoretical study, Russ. Chem. Bull., 60, 238–241, https://doi.org/10.1007/s11172-011-0039-5, 2011.
Kim, S. G. and Lee, J. S. J.: Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection, Mater. Chem. B, 9, 6076–6083, 2021.
Kipping, M., Tänzler, D., and Sinz, A.: A rapid and reliable liquid chromatography/mass spectrometry method for SARS-CoV-2 analysis from gargle solutions and saliva, Anal. Bioanal. Chem, 413, 6503, https://doi.org/10.1007/s00216-021-03614-y, 2021.
Kollman, P. A., Massova, I., Reyes, C., Kuhn, B., Huo, S., Chong, L., Lee, M., Lee, T., Duan, Y., Wang, W., Donini, O., Cieplak, P., Srinivasan, J., Case, D. A., and Cheatham, T. E.: III. Calculating structures and free energies of complex molecules: Combining molecular mechanics and continuum models, Acc. Chem. Res., 33, 889–897, 2000.
Kumar, S., Panwar, S., Augustine, S., and Malhotra, B. D.: Biofunctionalized Nanostructured Yttria Modified Non-Invasive Impedometric Biosensor for Efficient Detection of Oral Cancer, Nanomaterials, 9, 1190, https://doi.org/10.3390/nano9091190, 2019.
Lee, J., Yoon, K. H., Hwang, K. S., Park, J., Ahn, S., and Kim, T. S.: Label free novel electrical detection using micromachined PZT monolithic thin fi lm cantilever for the detection of Creactive protein, Biosens. Bioelectron., 20, 269–275, 2004.
Lee, W.-I., A. Subramanian, S., Mueller, K., Levon, C.-Y., and Nam, M. H.: Rafailovich, Potentiometric biosensors based on molecular-imprinted self-assembled monolayer films for rapid detection of influenza a virus and SARS-CoV-2 spike protein, ACS Appl. Nano Mater, 5, 5045, https://doi.org/10.1021/acsanm.2c00068, 2022.
Li, X., Yang, T., and Lin, J.: Spectral analysis of human saliva for detection of lung cancer using surface-enhanced Raman spectroscopy, J. Biomed. Opt., 17, 037003, https://doi.org/10.1117/1.JBO.17.3.037003, 2012.
Liang, H., Yin, B., Zhang, H., Zhang, S., Zeng, Q., and Wang, J.: Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-α signaling protected Wistar rats from diet-induced obesity and insulin resistance, Endocrinology, 149, 2943–2951, https://doi.org/10.1210/en.2007-0978, 2008.
Liu, C. Y., Tam, S. S., Huang, Y., Dubé, P. E., Alhosh, R., Girish, N., Punit, P., Nataneli, S., Li, F., Bender, J. M., Washington, M. K., and Polk, D. B.: TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice, Cell Reports, 33, 108275, https://doi.org/10.1016/j.celrep.2020.108275, 2020.
Liu, H., Yang, A., Song, J., Wang, N., Lam, P., Li, Y., Law, H. K.-W., and Yan, F.: Ultrafast, sensitive, and portable detection of COVID-19 IgG using flexible organic electrochemical transistors, Sci. Adv., 7, 8387, https://doi.org/10.1126/sciadv.abg8387, 2021.
Liu, Q., Liu, Y., Wu, F., Cao, X., Li, Z., Alharbi, M., Abbas, A.N., Amer, M.R., and Zhou, C.: Highly Sensitive and Wearable In2O3 Nanoribbon Transistor Biosensors with Integrated On-Chip Gate for Glucose Monitoring in Body Fluids, ACS Nano, 12, 1170–1178, 2018.
Liu, Q., Aroonyadet, N., Song, Y., Wang, X., Cao, X., Liu, Y., Cong, S., Wu, F., Thompson, M. E., and Zhou, C.: Highly Sensitive and Quick Detection of Acute Myocardial Infarction Biomarkers Using In2O3 Nanoribbon Biosensors Fabricated Using Shadow Masks, ACS Nano, 10, 10117–10125, 2016.
Liu, Y., Li, Y., Li, X.-M., and He, T.: Kinetics of (3-Aminopropyl)triethoxylsilane (APTES) Silanization of Superparamagnetic Iron Oxide Nanoparticles, Langmuir, 29, 15275–15282, 2013.
Macchia, E., Manoli, K., Holzer, B., Franco, C. D., Picca, R. A., Cioffi, N., Scamarcio, G., Palazzo, G., and Torsi, L.: Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor, Anal. Bioanal. Chem, 411, 4899, https://doi.org/10.1007/s00216-019-01778-2, 2019.
Mani, V., Beduk, T., Khushaim, W., Ceylan, A. E., Timur, S., Wolfbeis, O. S., and Salama, K. N.: Electrochemical sensors targeting salivary biomarkers: A comprehensive review TrAC, Trends Anal. Chem., 135, 116164, https://doi.org/10.1016/j.trac.2020.116164, 2021.
Mollaamin, F., Najafi, F., Khaleghian, M., Hadad, B. K., and Monajjemi, M.: Theoretical study of different solvents and temperatures effects on single-walled carbon nanotube and temozolomide drug: A QM/MM study, Fuller. Nanotub. Car. N., 19, 653–667, https://doi.org/10.1080/1536383X.2010.504956, 2011.
Mollaamin, F., Ilkhani, A., Sakhaei, N., Bonsakhteh, B., Faridchehr, A., Tohidi, S., and Monajjemi, M.: Thermodynamic and solvent effect on dynamic structures of nano bilayer-cell membrane: Hydrogen bonding study, J. Comput. Theor. Nanos., 12, 3148–3154, https://doi.org/10.1166/jctn.2015.4092, 2015.
Monajjemi, M., Afsharnezhad, S., Jaafari, M. R., Mirdamadi, S., Mollaamin, F., and Monajemi, H.: Investigation of energy and NMR isotropic shift on the internal rotation Barrier of Θ4 dihedral angle of the DLPC: A GIAO study, Chemistry, 17, 55–69, 2008.
Monajjemi, M., Khaleghian, M., Tadayonpour, N., and Mollaamin, F.: The effect of different solvents and temperatures on stability of single-walled carbon nanotube: A QM/MD study, Int. J. Nanosci., 9, 517–529, https://doi.org/10.1142/S0219581X10007071, 2010a.
Monajjemi, M., Noei, M., and Mollaamin, F.: Design of fMet-tRNA and calculation of its bonding properties by quantum mechanics, Nucleos. Nucleot. Nucl., 29, 676–683, https://doi.org/10.1080/15257771003781642, 2010b.
Monajjemi, M., Khosravi, M., Honarparvar, B., and Mollaamin, F. : Substituent and solvent effects on the structural bioactivity and anticancer characteristic of catechin as a bioactive constituent of green tea, Int. J. Quantum Chem., 111, 2771–2777, https://doi.org/10.1002/qua.22612, 2011.
Monajjemi, M., Yamola, H., and Mollaamin, F.: Study of bio-nano interaction outlook of amino acids on single-walled carbon nanotubes, Fuller. Nanotub. Car. N., 22, 595–603, https://doi.org/10.1080/1536383X.2012.702163, 2014.
Murao, K., Ohyama, T., Imachi, H., Ishida, T., Cao, W. M., and Namihira, H.: TNF-alpha stimulation of MCP-1 expression is mediated by the Akt/PKB signal transduction pathway in vascular endothelial cells, Biochem. Bioph. Res. Co., 276, 791–796, https://doi.org/10.1006/bbrc.2000.3497, 2000.
Nascimento, E. D., Fonseca, W. T., de Oliveira, T. R., de Correia, C. R. S. T. B., Faça, V. M., de Morais, B. P., Silvestrini, V. C., Pott-Junior, H., Teixeira, F. R., and Faria, R. C.: COVID-19 diagnosis by SARS-CoV-2 Spike protein detection in saliva using an ultrasensitive magneto-assay based on disposable electrochemical sensor, Sensor. Actuat. B-Chem., 353, 131128, https://doi.org/10.1016/j.snb.2021.131128, 2022.
Oh, B. K., Lee, W., Kim, Y. K., Lee, W. H., and Choi, J.-W.: Surface plasmon resonance immunosensor using self-assembled protein G for the detection of Salmonella paratyphi, J. Biotechnol., 111, 1–8, 2004.
Park, J., Sunkara, V., Kim, T.-H., Hwang, H., and Cho, Y.-K.: Lab-on-a-disc for fully integrated multiplex immunoassays, Anal. Chem., 84, 2133, https://doi.org/10.1021/ac203163u, 2012.
Patel, N., Belcher, J., Thorpe, G., Forsyth, N. R., and Spiteri, M. A.: Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters, Resp. Res., 16, 62, https://doi.org/10.1186/s12931-015-0219-1, 2015.
Pires, N. M. M., Dong, T., Yang, Z., Høivik, N., and Zhao, X.: A mediator embedded micro-immunosensing unit for electrochemical detection on viruses within physiological saline media, J. Micromech. Microeng., 21, 115031, https://doi.org/10.1088/0960-1317/21/11/115031, 2011.
Probert, L.: TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects, Neuroscience, 302, 2–22, https://doi.org/10.1016/j.neuroscience.2015.06.038, 2015.
Qu, Y., Zhao, G., and Li, H.: Forward and Reverse Signaling Mediated by Transmembrane Tumor Necrosis Factor-Alpha and TNF Receptor 2: Potential Roles in an Immunosuppressive Tumor Microenvironment, Front. Immunol., 8, 1675, https://doi.org/10.3389/fimmu.2017.01675, 2017.
Ramadori, G. and Armbrust, T.: Cytokines in the liver, Eur. J. Gastroen. Hepat., 13, 777–784, https://doi.org/10.1097/00042737-200107000-00004, 2001.
RasMol: Installation Instructions, RasMol 2.7.5, http://www.rasmol.org/software/rasmol/INSTALL.html, last access: 22 November 2024.
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., Sorsa, T., and Gustafsson, A.: Salivary Biomarkers for Detection of Systemic Diseases, PLoS One, 8, e61356, https://doi.org/10.1371/journal.pone.0061356, 2013.
Robin Li and Melissa Ma Science Library: General Overview of ChemDraw and Signals Notebook, Stanford Libraries, https://guides.library.stanford.edu/scilib-software/chemdraw, last access: 22 November 2024.
Rolski, F. and Błyszczuk, P.: Complexity of TNF-α Signaling in Heart Disease, J. Clin. Med., 9, 3267, https://doi.org/10.3390/jcm9103267, 2020.
Ryu, J., Lee, E., Lee, K., and Jang, J.: A graphene quantum dots based fluorescent sensor for anthrax biomarker detection and its size dependence, J. Mater. Chem. B, 3, 4865–4870, 2015.
Sali, A., Potterton, L., Yuan, F., van Vlijmen, H., and Karplus, M.: Evaluation of comparative protein modeling by MODELLER, Proteins, 23, 318–326, 1995.
Samavati, A., Samavati, Z., Velashjerdi, M., Ismail, A. F., Othman, M. H. D., Eisaabadi, B. G., Abdullah, M. S., Bolurian, M., and Bolurian, M.: Sustainable and fast saliva-based COVID-19 virus diagnosis kit using a novel GO-decorated Au/FBG sensor, Chem. Eng. J., 420, 127655, https://doi.org/10.1016/j.cej.2020.127655, 2021.
Sambrook, J., Fritsch, E. F., and Maniatis, T.: Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, NY, USA, ISBN (Hardback): 978-0-87969-309-1, 1989.
Sarasia, E. M., Afsharnezhad, S., Honarparvar, B., Mollaamin, F., and Monajjemi, M.: Theoretical study of solvent effect on NMR shielding tensors of luciferin derivatives, Phys. Chem. Liq., 49, 561–571, https://doi.org/10.1080/00319101003698992, 2011.
Sethi, J. K. and Hotamisligil, G. S.: Metabolic Messengers: tumour necrosis factor, Nature Metabolism, 3, 1302–1312, https://doi.org/10.1038/s42255-021-00470-z, 2021.
Soomro, R. A., Jawaid, S., Zhang, P., Han, X., Hallam, K. R., Karakuş, S., Kilislioğlu, A., Xu, B., and Willander, M.: NiWO4-induced partial oxidation of MXene for photo-electrochemical detection of prostate-specific antigen, Sensor. Actuat. B Chem., 328, 129074, https://doi.org/10.1016/j.snb.2020.129074, 2021.
Sugita, Y. and Okamoto, Y.: Replica-exchange molecular dynamics method for protein folding, Chem. Phys. Lett., 314, 141–151, 1999.
Tabrizi, M. A. and Acedo, P.: An electrochemical membrane-based aptasensor for detection of severe acute respiratory syndrome coronavirus-2 receptor-binding domain, Appl. Surf. Sci., 598, 153867, https://doi.org/10.1016/j.apsusc.2022.153867, 2022.
Tabrizi, M. A., Nazari, L., and Acedo, P.: A photo-electrochemical aptasensor for the determination of severe acute respiratory syndrome coronavirus 2 receptor-binding domain by using graphitic carbon nitride-cadmium sulfide quantum dots nanocomposite, Sensor. Actuat. B-Chem., 345, 130377, https://doi.org/10.1016/j.snb.2021.130377, 2021.
TBI (Taiwan Bioinformatics Institute): iGEMDOCK Generic Evolutionary Method for molecular DOCKing, https://www.tbi.org.tw/tools/download.php, last access: 22 November 2024.
Tomczak, M., Gupta, M., Drummy, L., Rozenzhak, S., and Naik, R.: Morphological control and assembly of zinc oxide using a biotemplate, Acta Biomater., 5, 876–882, 2009.
Torrente-Rodríguez, R. M., Campuzano, S., Ruiz-Valdepeñas Montiel, V., Gamella, M., and Pingarrón, J. M.: Electrochemical bioplatforms for the simultaneous determination of interleukin (IL)-8 mRNA and IL-8 protein oral cancer biomarkers in raw saliva, Biosens. Bioelectron., 77, 543, https://doi.org/10.1016/j.bios.2015.10.016, 2016.
Vilian, A. T. E., Kim, W., Park, B., Oh, S. Y., Kim, T., Huh, Y. S., Hwangbo, C. K., and Han, Y.-K.: Efficient electrn-mediated electrochemical biosensor of gold wire for the rapid detection of C-reactive protein: A predictive strategy for heart failure, Biosens. Bioelectron., 142, 111549, https://doi.org/10.1016/j.bios.2019.111549, 2019.
Wallace, A. C., Laskowski, R. A., and Tornton, J. M.: LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions, Protein Eng., 8, 127–134, 1995.
Wandrer, F., Liebig, S., Marhenke, S., Vogel, A., John, K., Manns, M. P., Teufel, A., Itzel, T., Longerich, T., Maier, O., Fischer, R., Kontermann, R. E., Pfizenmaier, K., Schulze-Osthoff, K., and Bantel, H.: TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice, Cell Death Dis., 11, 212, https://doi.org/10.1038/s41419-020-2411-6, 2020.
Wang, X., Kaczor-Urbanowicz, K. E., and Wong, D. T. W.: Salivary Biomarkers in Cancer Detection, Med. Oncol., 34, 7, https://doi.org/10.1007/s12032-016-0863-4, 2017.
Wang, R., Lai, L., and Wang, S.: Further development and validation of empirical scoring functions for structure-based binding affinity prediction, J. Comput. Aid. Mol. Des., 16, 11–26, 2002.
Wei, F., Yang, J., and Wong, D. T. W.: Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM), Biosens. Bioelectron., 44, 115, https://doi.org/10.1016/j.bios.2012.12.046, 2013.
Xiao, H., Zhang, Y., Kim, Y., Kim, S., Kim, J. J., Kim, K. M., Yoshizawa, J., Fan, L.-Y., Cao, C.-X., and Wong, D. T. W.: Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection, Sci. Rep., 6, 22165, https://doi.org/10.1038/srep22165, 2016.
Yousefi, H., Mahmud, A., Chang, D., Das, J., Gomis, S., Chen, J. B., Wang, H., Been, T., Yip, L., Coomes, E., Li, Z., Mubareka, S., McGeer, A., Christie, N., Gray-Owen, S., Cochrane, A., Rini, J. M., Sargent, E. H., and Kelley, S. O.: Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing, J. Am. Chem. Soc., 143, 1722–1727, https://doi.org/10.1021/jacs.0c10810, 2021.
Zadeh, M. A. A., Lari, H., Kharghanian, L., Balali, E., Khadivi, R., Yahyaei, H., Mollaamin, F., and Monajjemi, M.: Density functional theory study and anti-cancer properties of shyshaq plant: In view point of nano biotechnology, J. Comput. Theor. Nanos., 12, 4358–4367, https://doi.org/10.1166/jctn.2015.4366, 2015.
Zamora-Mendoza, B. N., Espinosa-Tanguma, R., Ramírez-Elías, M. G., Cabrera-Alonso, R., Montero-Moran, G., Portales-Pérez, D., Rosales-Romo, J. A., Gonzalez, J. F., and Gonzalez, C.: Surface-enhanced raman spectroscopy: A noninvasive alternative procedure for early detection in childhood asthma biomarkers in saliva, Photodiagn. Photodyn., 27, 85–91, 2019.
Zhang, Z., Pandey, R., Li, J., Gu, J., White, D., Stacey, H. D., Ang, J. C., Steinberg, C.-J., Capretta, A., Filipe, C. D. M., Mossman, K., Balion, C., Miller, M. S., Salena, B. J., Yamamura, D., Soleymani, L., Brennan, J. D., and Li, Y.: High-Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva, Angew. Chem. Int. Edit., 60, 24266–24274, https://doi.org/10.1002/anie.202110819, 2021.
Zheng, G., Patolsky, F., Cui, Y., Wang, W. U., and Lieber, C. M.: Multiplexed electrical detection of cancer markers with nanowire sensor arrays, Nat. Biotechnol., 23, 1294–1301, 2005.
Short summary
We present a sensor platform that can detect the oral cancer signature of biomarkers in saliva. This system works by arraying metal–oxide–semiconductor field-effect transistors (MOSFETs) and electrolyte-gated transistors (EGTs), with each targeting a biorecognition element (BRE) from a DNA sequence found in the promoter region of most biomarker genes. This system is also applicable to the simultaneous diagnosis of TNF-α and IL-1β immune-modulator biomarkers.
We present a sensor platform that can detect the oral cancer signature of biomarkers in saliva....