Articles | Volume 13, issue 2
https://doi.org/10.5194/jsss-13-245-2024
https://doi.org/10.5194/jsss-13-245-2024
Regular research article
 | 
10 Dec 2024
Regular research article |  | 10 Dec 2024

A portable biosensor for simultaneous diagnosis of TNF-α and IL-1β in saliva biomarkers using twin electronic devices

Majid Monajjemi, Fatemeh Mollaamin, Motahareh Dehghandar, Sara Shahriari, Parisa Latifi, and Samira Mohammadi

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Cited articles

Abayomi, L. A., Terry, L. A., White, S. F., and Warner, P. J.: Development of a disposable pyruvate biosensor to determine pungency in onions (Allium cepa L.), Biosens. Bioelectron., 21, 2176–2179, https://doi.org/10.1016/j.bios.2005.10.024, 2006. 
Arif, S., Qudsia, S., Urooj, S., Chaudry, N., Arshad, A., and Andleeb, S.: Blueprint of quartz crystal microbalance biosensor for early detection of breast cancer through salivary autoantibodies against ATP6AP1, Biosens. Bioelectron., 65, 62–70, https://doi.org/10.1016/j.bios.2014.09.088, 2015. 
Andrusier, N., Nussinov, R., and Wolfson, H. J.: FireDock: Fast Interaction Refinement in Molecular Docking, Proteins, 69, 139–159, https://doi.org/10.1002/prot.21495, 2007. 
Andrusier, N., Mashiach, E., Nussinov, R., and Wolfson, H. J.: Principles of flexible protein–protein docking, Proteins, 73, 271–289, https://doi.org/10.1002/prot.22170, 2008. 
Aroonyadet, N., Wang, X., Song, Y., Chen, H., Cote, R. J., Thompson, M. E., Datar, R. H., and Zhou, C.: Highly Scalable, Uniform, and Sensitive Biosensors Based on Top-Down Indium Oxide Nanoribbons and Electronic Enzyme-Linked Immunosorbent Assay, Nano Lett., 15, 1943–1951, https://doi.org/10.1021/nl5047889, 2015. 
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Short summary
We present a sensor platform that can detect the oral cancer signature of biomarkers in saliva. This system works by arraying metal–oxide–semiconductor field-effect transistors (MOSFETs) and electrolyte-gated transistors (EGTs), with each targeting a biorecognition element (BRE) from a DNA sequence found in the promoter region of most biomarker genes. This system is also applicable to the simultaneous diagnosis of TNF-α and IL-1β immune-modulator biomarkers.